Process planning and scheduling are two key sub-functions in the manufacturing system. Traditionally, process planning and scheduling were regarded as the separate tasks to perform sequentially. Recently, a significant trend is to integrate process planning and scheduling more tightly to achieve greater performance and higher productivity of the manufacturing system. Because of the complementarity of process planning and scheduling, and the multiple objectives requirement from the real-world production, this research focuses on the multi-objectiv integrated process planning and scheduling (IPPS) problem. In this research, the Nash equilibrium in game theory based approach has been used to deal with the multiple objectives. And a hybrid algorithm has been developed to optimize the IPPS problem. Experimental studies have been used to test the performance of the proposed approach. The results show that the developed approach is a promising and very effective method on th research of the multi-objective IPPS problem